PDGF VS PRP

In the world of aesthetic treatments, trends come and go—but regenerative therapies are here to stay. Platelet-Rich Plasma (PRP) was once hailed as a game-changer in skin rejuvenation, offering a natural approach to smoother, healthier, more youthful-looking skin. But now, the industry is shifting toward a more advanced and precise solution: Platelet-Derived Growth Factor (PDGF).

If you’re exploring regenerative aesthetics—especially treatments to improve skin texture, tone, firmness, or recovery—understanding the difference between PRP and PDGF could transform your results. Here’s why PDGF is leading the next evolution in aesthetic medicine.

WHAT IS PRP?

PRP, or Platelet-Rich Plasma, is a regenerative treatment that uses a patient’s own blood to promote healing and rejuvenation. The process involves drawing a small amount of blood, then spinning it in a centrifuge to isolate the platelet-rich portion. These platelets are packed with growth factors that help stimulate collagen production, enhance tissue repair, and support cellular regeneration. In aesthetics, PRP is commonly used for facial rejuvenation (often called the “vampire facial”), hair restoration, and to speed recovery after procedures like microneedling or laser treatments.

While PRP can be effective, its results can vary depending on the individual’s natural platelet levels. For this reason, lab-derived alternatives like PDGF+—which deliver a consistent and significantly higher concentration of growth factors—are becoming a preferred option for more reliable and potent skin rejuvenation (more on that below).

ENTER: PDGF - THE FUTURE OF REGENERATIVE AESTHETICS

Platelet-Derived Growth Factor (PDGF) is one of the most powerful and well-researched growth factors naturally found in the body, known for its essential role in skin repair, collagen remodeling, and cellular regeneration. PDGF+ delivers an impressive 100,000 to 300,000 times the growth factor concentration found in competitive products—meaning fewer applications, faster results, and more satisfied clients.

What truly sets PDGF+ apart is its pharmaceutical-grade consistency and reliability. Unlike platelet-based treatments that depend on drawing and processing a patient’s own blood, PDGF+ provides a standardized dose with every application. This eliminates variability for providers while ensuring a safe, natural, and effective solution for clients. The formula is also exceptionally clean, containing only four ingredients: water, sodium acetate, hyaluronic acid, and sh-polypeptide-59 dimer—making it as pure as it is potent.

PDGF isn’t just promising—it’s proven. It serves as the active ingredient in four FDA-approved medical treatments (GEM 21S®, Augment®, Augment® Injectable, and Regranex®) and has helped treat over five million patients in the past 15 years. Now, that same trusted science is available in PDGF+, offering medical-grade regeneration tailored to modern aesthetic care.

It’s also incredibly versatile: PDGF+ can be used topically or injected, depending on the treatment approach. When injected, it penetrates deep into the dermis for structural skin regeneration. When applied topically—especially after microneedling, when absorption is maximized—it delivers powerful rejuvenating benefits at the surface level. This dual functionality makes PDGF+ a breakthrough solution for comprehensive skin revitalization.

PDGF gives you all the beauty-boosting benefits of PRP—without the variability or limitations.

3 REASONS PDGF OUTPERFORMS PRP:

1. Precision Over Guesswork

PRP is a blend of platelets, plasma, and a mix of growth factors—some helpful, some irrelevant, and some that may even trigger inflammation. PDGF is focused. It zeroes in on what truly works to promote skin regeneration, boost collagen, and improve elasticity and tone—without filler ingredients.

2. Consistent Results

With PRP, two people can get very different results from the exact same treatment protocol. With PDGF, you get pharmaceutical-grade precision. Every treatment delivers the same concentration of regenerative growth factor—meaning more predictable, reliable outcomes in fewer sessions.

3. Science-Backed Superiority

PDGF plays a critical role in stimulating fibroblasts (your skin’s collagen factories), increasing dermal thickness, and accelerating healing post-procedure. When used in aesthetic applications—whether post-laser, after microneedling, or as part of a topical regimen—PDGF helps the skin recover faster and look fresher, firmer, and more radiant.

FINAL THOUGHTS ON WHY PDGF IS BETTER THAN PRP

PRP opened the door to natural regeneration. PDGF walks through it with clinical precision, delivering better skin outcomes with less biological variability. In aesthetic medicine, where results matter and consistency counts, PDGF is the clear choice for anyone serious about skin rejuvenation.

GET CONTOURED

If you have any questions about PDGF, we are here to help! You can reach us at (720) 629-8921, or you can book a New Client Consultation to learn more. We're happy to answer any questions you may have and guide you through the process.